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Formaldehyde → 1-(4-Chlorophenyl)-5-[(3,3-difluoro-1-pyrrolidinyl)methyl]-1H-tetrazole

HRID 517761
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반응식

HRID 517761 반응식
Cl.[F:2][C:3]1([F:8])[CH2:7][CH2:6][NH:5][CH2:4]1.C=O.C([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])C.[Cl:18][C:19]1[CH:24]=CC([N+]#[C-])=[CH:21][CH:20]=1.C[Si]([N:31]=[N+:32]=[N-:33])(C)C>CO>[Cl:18][C:19]1[CH:24]=[CH:17][C:16]([N:13]2[C:14]([CH2:15][N:5]3[CH2:6][CH2:7][C:3]([F:8])([F:2])[CH2:4]3)=[N:33][N:32]=[N:31]2)=[CH:21][CH:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 712FormaldehydeHCID 8471TriethylamineHCID 746704-Chlorophenyl isocyanideHCID 78378AzidotrimethylsilaneHCID 249034823,3-Difluoropyrrolidine hydrochloride

생성물 1

HCID 680745081-(4-Chlorophenyl)-5-[(3,3-difluoro-1-pyrrolidinyl)methyl]-1H-tetrazole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3,3-difluoropyrrolidine hydrochloride (129 mg, 0.90 mmol, Sigma-Aldrich) in methanol (3 mL) was added formaldehyde (37% aqueous) (0.067 mL, 0.90 mmol) and triethylamine (0.139 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for 2 hours. To the reaction mixture was added 4-chlorophenyl isocyanide (138 mg, 1.00 mmol) and trimethylsilylazide (0.133 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for a further 18 hours.

후처리

  1. stirringThe reaction mixture was shaken at room temperature for a further 18 hours

출처 및 근거

ORD 기록
ord-cd43199020bd453d94a2a1123bc5b8fa
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09115132B2

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