반응식
[CH2:1]([N:8]1[CH2:24][CH2:23][C:11]2([NH:20][C:19](=[O:21])[C:18]3[C:13](=[CH:14][CH:15]=[C:16](Br)[CH:17]=3)[NH:12]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])(=[O:28])[CH:26]=[CH2:27].COC(=O)/C=C/C1C=C2C(=CC=1)OC1(CCN(C(OC(C)(C)C)=O)CC1)CC2=O>>[C:30]([O:29][C:25](=[O:28])/[CH:26]=[CH:27]/[C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]1([CH2:23][CH2:24][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:9][CH2:10]1)[NH:20][C:19]2=[O:21])([CH3:33])([CH3:32])[CH3:31]참가 물질
4
반응물 3
생성물 1
실험 절차
(E)-3-{1-Benzyl-3′,4′-dihydro-4′-oxo-spiro[piperidine-4,2′(1′H)-quinazoline]-6′-yl}-acrylic acid tert-butyl ester was synthesized starting from 1-benzyl-6′-bromo-3′,4′-dihydro-spiro[piperidine-4,2′(1′H)-quinazoline]-4′-one (600 mg, 1.55 mmol) and tert-butyl acrylate according to the procedure described for Intermediate 1, Step B, giving 486 mg of the product.
출처 및 근거
- ORD 기록
- ord-5683ea6afdaa4f3cae33f709d6e8add1
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115148B2
연결된 노트
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