Iodoethane → N-(7-Diethylamino-4-methoxy-benzothiazol-2-yl)-4-fluoro-benzamide

HRID 51870

반응식

HRID 51870 반응식
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11]C=2C(N)=C[CH:4]=1.C(=O)([O-])[O-].[K+].[K+].ICC.[F:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=O)=[CH:26][CH:25]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:57]([N:59]([CH:63]([CH3:65])C)[CH:60]([CH3:62])[CH3:61])[CH3:58]>CN(C=O)C.C1COCC1>[CH2:63]([N:59]([CH2:57][CH3:58])[C:60]1[C:61]2[S:11][C:10]([NH:12][C:28](=[O:30])[C:27]3[CH:26]=[CH:25][C:24]([F:23])=[CH:32][CH:31]=3)=[N:9][C:8]=2[C:3]([O:2][CH3:1])=[CH:4][CH:62]=1)[CH3:65]

참가 물질

9

반응물 6

HCID 6340IodoethaneHCID 99734-Fluorobenzoic AcidHCID 11430Potassium CarbonateHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 227369774-Methoxy-1,3-benzothiazole-2,7-diamine

생성물 1

HCID 22737008N-(7-Diethylamino-4-methoxy-benzothiazol-2-yl)-4-fluoro-benzamide

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

실험 절차

From 4-methoxy-benzothiazole-2,7-diamine with potassium carbonate and iodoethane in DMF, then treatment with 4-fluoro-benzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 374 (M+H+, 100).

출처 및 근거

ORD 기록
ord-2064d60db8714019813c196f75708058
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713499B2

연결된 노트

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