Hydrochloric Acid → 4-bromo-2-chloro-1H-indole

HRID 520599노트

반응식

HRID 520599 반응식
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([Cl:21])[N:6]2S(C1C=CC(C)=CC=1)(=O)=O.[OH-].[Na+].Cl>CC(O)C>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([Cl:21])[NH:6]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 682264944-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole

생성물 1

HCID 197003094-bromo-2-chloro-1H-indole

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
120 °C

실험 절차

4-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole (215 mg), IPA (2.5 ml) and 2 M NaOH (aq) (2.5 ml) were mixed in a microwave vial and heated in the microwave for 30 min at 120° C. The reaction was acidified using 2M HCl (aq) and then extracted with DCM, which was passed through a hydrophobic frit, then evaporated to dryness. The residue was triturated with methanol which was then evaporated to afford the title compound, 112 mg.

후처리

  1. extractionextracted with DCM, which
  2. customevaporated to dryness
  3. customThe residue was triturated with methanol which
  4. customwas then evaporated

출처 및 근거

ORD 기록
ord-d646c431cbbf481e812a3bc780829b0b
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326987B2

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