Hydrochloric Acid → 2-Chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoic acid
반응식
[Cl:1][C:2]1[CH:11]=[C:10]([F:12])[C:9]([C:13]2[C:18]([F:19])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[Li+].[OH-].O.Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[C:10]([F:12])[C:9]([C:13]2[C:18]([F:19])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]참가 물질
6
실험 절차
To a mixture of methyl 2-chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoate (Preparation 36, 240 mg, 0.85 mmol) in ethanol (5 mL) was added 2M LiOH in water (2.1 mL, 4.23 mmol). The reaction was stirred at room temperature for 1 hour before neutralising with 2M HCl (aq). The resulting precipitate was collected, washed with water and dried to afford the title compound as a white solid (160 mg, 70%).
후처리
- customThe resulting precipitate was collected
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-55f593576f824427b55ec44877b66e62
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09328096B2
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