Diisopropylethylamine → HCID 178461598, 화합물

HRID 522802노트

반응식

HRID 522802 반응식
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][C@H:12]2[CH3:17])[N:3]=1.C(N(C(C)C)CC)(C)C.Cl.[CH3:28][C@@H:29]1[CH2:34][O:33][CH2:32][CH2:31][NH:30]1>CC(O)CC.C(Cl)Cl>[CH3:28][C@@H:29]1[CH2:34][O:33][CH2:32][CH2:31][N:30]1[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][C@H:12]2[CH3:17])[N:3]=1

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 57356922(3R)-3-Methylmorpholine hydrochlorideHCID 178461592HCID 178461592, 화합물

생성물 1

HCID 178461598HCID 178461598, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6568(+-)-2-Butanol용매

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온도
180 °C

실험 절차

2-Chloro-6-((R)-3-methyl-morpholin-4-yl)-9H-purine (1.02 g, 4 mmol), diisopropylethylamine (1.40 mL, 8 mmol), and (R)-3-methylmorpholin hydrochloride (826 mg, 6 mmol) were stirred in 2-butanol (5 mL) in a closed microwave tube under argon at 50° C., until all ingredients were dissolved. The reaction was then stirred at 180° C. for 100 hours. The reaction mixture was then cooled to room temperature and diluted with 200 mL of CH2Cl2.

후처리

  1. dissolutionwere dissolved
  2. temperatureThe reaction mixture was then cooled to room temperature

출처 및 근거

ORD 기록
ord-b947f4e924834d29af0e3d3298ae2880
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09334271B2

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