Cyclopentanone → HCID 70982889, 화합물

HRID 523589노트

반응식

HRID 523589 반응식
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[C:8]1(=[O:13])[CH2:12][CH2:11][CH2:10][CH2:9]1.[Li]CCCC.C(N(C(C)C)CC)(C)C>C1COCC1>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1([OH:13])[CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

6

반응물 4

HCID 8452CyclopentanoneHCID 122863-BromopyridineHCID 81531DiisopropylethylamineHCID 178418339Butyllithium

생성물 1

HCID 70982889HCID 70982889, 화합물수율 34%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Using analogous reaction condition and reagents as described in Example 20 for the preparation of I-20a above, 3-bromo pyridine solution (1.0 g, 6.36 mmol) was reacted with cyclopentanone solution (0.6 mL, 70 mmol) in dry THF (6 mL), n-BuLi solution (4.0 mL, 7.6 mmol) and diisopropylethyl amine (1.0 mL, 70 mmol) in dry THF (6 mL) to afford the crude product. The crude was purified by column chromatography on silica gel (20% ethyl acetate in hexane) afforded 520 mg of the product (34% yield).

후처리

  1. customto afford the crude product
  2. customThe crude was purified by column chromatography on silica gel (20% ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-ef14f93232014c65abed3fabb3e69306
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09339501B2

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