Ethyl Acetoacetate → Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate

HRID 524726

반응식

HRID 524726 반응식
Cl.[N:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8](=[NH:10])[NH2:9].[Cl:11][C:12]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:13]=1[CH:14]=O.O=[C:22]([CH3:29])[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[Cl:11][C:12]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:13]=1[CH:14]1[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:22]([CH3:29])[NH:9][C:8]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][N:2]=2)=[N:10]1

참가 물질

4

반응물 3

HCID 8868Ethyl AcetoacetateHCID 1450242-Chloro-4-fluorobenzaldehydeHCID 470895Pyrazine-2-carboxamidine hydrochloride

생성물 1

HCID 118107549Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate수율 41%

실험 절차

Pyrazine-2-carboximidamide hydrochloride (5 g, 31.5 mmol) was reacted with 2-chloro-4-fluorobenzaldehyde (5 g, 31.5 mmol) and ethyl 3-oxobutanoate (4.1 g, 31.5 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (4.84 g, 41%). The compound was characterized by the following spectroscopic data:

출처 및 근거

ORD 기록
ord-2df5724b920746949c2d5f84a29dc7d2
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09340538B2

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