Hydrochloric Acid → 3-Amino-2-hydroxycyclohexane-1-carboxylic acid

HRID 527058노트

반응식

HRID 527058 반응식
[OH:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl>O=[Pt]=O>[NH2:11][CH:10]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH:2]1[OH:1]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68073-Nitrosalicylic acid

생성물 1

HCID 672865413-Amino-2-hydroxycyclohexane-1-carboxylic acid

시약·촉매·용매 1

HCID 345198Adams' catalyst촉매

실험 절차

2-Hydroxy-3-nitro-benzoic acid (5.0 g, 27.3 mmol) was mixed with HCl (125 mL of 0.5 M, 62.5 mmol) and dioxoplatinum (1.0 g, 4.4 mmol) in a hydrogenation bottle. The mixture was placed on a Parr shaker (50 psi H2) for 24 hours. The catalyst was filtered and washed with hot H2O. The filtrate was evaporated to provide 3-amino-2-hydroxy-cyclohexanecarboxylic acid as a mixture of stereoisomers which was utilized to the next step without further purification.

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with hot H2O
  3. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-cf6bcba6db304c449b33de6ed56e92f1
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09345708B2

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