Sodium Hydroxide → 3'-Amino-4'-hydroxyacetophenone

HRID 5279

반응식

HRID 5279 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[OH:13])([O-])=O.[OH-].[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:1][C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[OH:13]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24489Sodium DithioniteHCID 1387234-Hydroxy-3-Nitroacetophenone

생성물 1

HCID 137241423'-Amino-4'-hydroxyacetophenone수율 39.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a 300 ml three-neck flask, 5.00 g (27.6 m mole) of 2-nitro-4-acetylphenol and 75 ml of 2N-sodium hydroxide solution were placed. To the mixture solution, a solution, which 25.00 g of sodium hydrosulfite was dissolved in 75 ml to water, was added dropwise in 10 minutes. Then the mixture solution was stirred for 20 minutes at room temperature to precipitate a crystal. The crystal was filtered and recrystallized from a mixture solvent of methanol-water to obtain 1.63 g of 2-amino-4-acetylphenol (Yield: 39.1%).

후처리

  1. additionwas added dropwise in 10 minutes
  2. customto precipitate a crystal
  3. filtrationThe crystal was filtered
  4. customrecrystallized from a mixture solvent of methanol-water

출처 및 근거

ORD 기록
ord-38e673fe1a454cec8a6dc24ef59e2c1c
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244596

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