Hydrochloric Acid → 2-Quinolinemethanol

HRID 52841

반응식

HRID 52841 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[O:12].[BH4-].[Na+].Cl>C(O)C>[OH:12][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 796192-QuinolinecarboxaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 731962-Quinolinemethanol수율 88%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3.0 g of quinoline-2-carboxaldehyde in 100 ml of ethanol was treated with 750 mg of sodium borohydride and stirred at ambient temperature for 15 min. The resulting solution was neutralized with 1N HCl, concentrated in vacuo, and extracted three times with ethyl acetate. The combined organic layers were dried over Na2SO4 and concentrated to provide 2.65 g (88%) of the crude desired compound.

후처리

  1. concentrationconcentrated in vacuo
  2. extractionextracted three times with ethyl acetate
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1ab4b932eb7a44b190073a611411ade3
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616714

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