Hydrochloric Acid → HCID 178440151, 화합물

HRID 52907노트

반응식

HRID 52907 반응식
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:31][CH2:32][CH3:33])[N:6]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:7]=1[C:8]([O:10]CC)=[O:9].O.[OH-].[Li+].Cl>O>[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:31][CH2:32][CH3:33])[N:6]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:18][CH:19]=2)[C:7]=1[C:8]([OH:10])=[O:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 178440150HCID 178440150, 화합물

생성물 1

HCID 178440151HCID 178440151, 화합물수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 0.20 g of ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 35(c)] and 0.10 g of lithium hydroxide monohydrate in 3 ml of water was stirred at room temperature for 3 hours, after which it was allowed to stand for 16 hours at the same temperature. The reaction mixture was then mixed with 2.38 ml of 1N aqueous hydrochloric acid and the resulting precipitate was collected by filtration, to give 150 mg of the title compound, melting a=233° C. (with decomposition).

후처리

  1. waitto stand for 16 hours at the same temperature
  2. filtrationthe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-4cf08a5710a44f68a929c2adcc952f18
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616599

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