Propargyl bromide → 2,4-dinitro-N-(2-(prop-2-ynyloxy)ethyl)aniline

HRID 532083

반응식

HRID 532083 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH:13][CH2:14][CH2:15][OH:16])([O-:3])=[O:2].[H-].[Na+].[CH2:19](Br)[C:20]#[CH:21]>CN(C=O)C.C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH:13][CH2:14][CH2:15][O:16][CH2:21][C:20]#[CH:19])([O-:3])=[O:2]

참가 물질

6

반응물 3

HCID 7842Propargyl bromideHCID 24758Sodium hydrideHCID 74757Ethanol, 2-((2,4-dinitrophenyl)amino)-

생성물 1

HCID 580788592,4-dinitro-N-(2-(prop-2-ynyloxy)ethyl)aniline수율 64.9%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6228Dimethylformamide용매2회

반응 조건

온도
0 °C

실험 절차

2-(2,4-dinitrophenylamino)ethanol (s-1a) (410 mg, 1.80 mmol, 1.0 equiv.) was dissolved in 3 mL of DMF and slowly added to a slurry of NaH (86.4 mg, 3.6 mmol, 2 equiv.) in 5 mL of DMF in a flame dried flask pre-cooled to 0° C. To the resulting slurry, 80% propargyl bromide (0.240 mL, 2.16 mmol, 1.2 equiv.) in toluene, cooled to 0° C., was added slowly. The ice bath was removed and the reaction was allowed to stir at room temperature for an additional 15 hours. The reaction was then re-cooled to 0° C., quenched with saturated NH4Cl, and extracted with diethyl ether (3×150 mL). The organic layers were combined, dried, concentrated under reduced pressure, and chromatographed (silica gel, 1×25 cm, 0% CH3OH in CHCl3, then 2.5% CH3OH in CHCl3) to yield 2,4-dinitro-N-(2-(prop-2-ynyloxy)ethyl)aniline (s-2a) as a dark yellow solid (310 mg, 64.8%). IR (thin film) 3356 (m), 3285 (m), 3105 (w), 2871 (w), 2117 (w), 1616 (s), 1584 (s), 1521 (s), 1499 (m), 1423 (m), 1274 (s), 1089 (s), 920 (m); 1H NMR (400 MHz, CDCl3) δ 9.16 (d, J=2.6 Hz, 1H), 8.76 (bs, 1H), 8.28 (dd, J=9.5, 2.7 Hz, 1H), 6.96 (d, J=9.5 Hz, 1H), 4.25 (d, J=2.4 Hz, 2H), 3.91-3.84 (m, 2H), 3.65 (d, J=5.3 Hz, 1H), 2.50 (t, J=2.4 Hz, 1H). 13C NMR (125 MHz, CDCl3) δ 149.5, 136.3, 130.7, 130.4, 124.4, 114.1, 78.9, 75.5, 67.3, 58.7, 43.3. HRMS (ES+) calc'd for C11H11N3O5 (M+H) m/z 266.0732 Found 266.0771.

후처리

  1. customdried flask
  2. additionwas added slowly
  3. customThe ice bath was removed
  4. temperatureThe reaction was then re-cooled to 0° C.
  5. customquenched with saturated NH4Cl
  6. extractionextracted with diethyl ether (3×150 mL)
  7. customdried
  8. concentrationconcentrated under reduced pressure
  9. customchromatographed (silica gel, 1×25 cm, 0% CH3OH in CHCl3

출처 및 근거

ORD 기록
ord-d1d3858064924b449b091346f13d72dc
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08852630B2

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