Sodium Hydroxide → 4-(4-Fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

HRID 532290노트

반응식

HRID 532290 반응식
C[O:2][C:3]([C:5]1[S:29][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH2:22][CH:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[C:7]=2[C:6]=1[CH3:30])=[O:4].[OH-].[Na+]>C(O)C.ClCCl.Cl>[F:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:30])=[C:5]([C:3]([OH:4])=[O:2])[S:29][C:8]=3[N:9]=[CH:10][N:11]=2)=[C:15]([O:21][CH2:22][CH:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH:16]=1

참가 물질

6

반응물 2

HCID 14798Sodium HydroxideHCID 58413397Methyl-4-(4-fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

생성물 1

HCID 584133504-(4-Fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

Methyl-4-(4-fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (82 mg) and NaOH (2M; 0.5 ml) was dissolved in ethanol (2 ml). The reaction was stirred at room temperature overnight. Then the reaction mixture was diluted with dichloromethane and HCl (2M). The suspension was filtered, washed with brine and ether. The residue was dried in vacuo over P2O5.

후처리

  1. filtrationThe suspension was filtered
  2. washwashed with brine and ether
  3. dry with materialThe residue was dried in vacuo over P2O5

출처 및 근거

ORD 기록
ord-ddeaacbfc298488796da70ee55d7cc81
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853193B2

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