Dimethyl Sulfoxide → 6-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol

HRID 533925

반응식

HRID 533925 반응식
CS(C)=O.[OH:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([OH:14])=O)=[N:10][CH:11]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.O[NH:28][C:29](=[NH:33])[CH:30]([CH3:32])[CH3:31]>CC(=O)OCC>[CH:30]([C:29]1[N:33]=[C:12]([C:9]2[N:10]=[CH:11][C:6]([OH:5])=[CH:7][CH:8]=2)[O:14][N:28]=1)([CH3:32])[CH3:31]

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 682631,1'-CarbonyldiimidazoleHCID 2687405-Hydroxypyridine-2-carboxylic acidHCID 178449908HCID 178449908, 화합물

생성물 1

HCID 1363773006-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
90 °C

실험 절차

To DMSO (25 mL) was added 5-hydroxy-pyridine-2-carboxylic acid (1.0 g) and CDI (1.3 g). After 15 minutes N-hydroxy-isobutyramidine (820 mg) was added. After 1 hour the mixture was heated to 90° C. for 1 hour. After the mixture reached room temperature, it was diluted with EA and washed three times with HCl (0.1 M). The organic phase was dried (Na2SO4) and concentrated to provide the title compound. MS ESI+: m/z=206 [M+H]+.

후처리

  1. customreached room temperature
  2. washwashed three times with HCl (0.1 M)
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-989f920584734f61b7577085f4131722
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853412B2

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