Hydrochloric Acid → 2-Tert-butyl-4-chloroaniline
반응식
[C:1]([C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[NH:12]C(=O)C)([CH3:4])([CH3:3])[CH3:2].Cl.[OH-].[Na+]>CCO>[C:1]([C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[NH2:12])([CH3:4])([CH3:2])[CH3:3]참가 물질
5
반응 조건
- 온도
- 110 °C
실험 절차
A mixture of N-(2-tert-butyl-4-chlorophenyl)acetamide (Reference Example 18, 4.78 g, 21.2 mmol), concentrated HCl (50 mL) and EtOH (10 mL) was stirred at 110° C. for 5 h. After cooling, the reaction mixture was basified with 8 M NaOH under ice-cooling. The mixture was extracted with ethyl acetate and the organic layer was washed with water, and saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (4.29 g) as a colorless oil.
후처리
- temperatureAfter cooling
- temperaturecooling
- extractionThe mixture was extracted with ethyl acetate
- washthe organic layer was washed with water, and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-05696247048843038986c648ec9e7acd
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08853215B2
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