Iodine → 2-Chloro-3-iodopyridin-4-amine
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-:15].[K+].II.[OH-].[Na+].S([O-])([O-])(=O)=S.[Na+].[Na+]>O>[Cl:1][C:2]1[C:7]([I:15])=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1참가 물질
8
반응 조건
- 온도
- 100 °C
실험 절차
Commercially available 2-chloro-4-aminopyridine (15 g, 0.1 mol) and 37.2 g (0.4 mol) of sodium carbonate are suspended in 200 ml of water and warmed to 100° C. 58.3 g (0.4 mol) of potassium iodide and 59.4 g (0.2 mol) of iodine are added to the resultant solution, and the mixture is stirred at the temperature indicated for 12 h. The mixture is subsequently adjusted to pH 13 using sodium hydroxide solution, treated with sodium thiosulfate until completely decolorised and extracted with ethyl acetate. Chromatographic purification gives 5 g (17%) of solid.
후처리
- extractionextracted with ethyl acetate
- customChromatographic purification
출처 및 근거
- ORD 기록
- ord-a5e1bc3944384b66943ecd4470c3c552
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08859581B2
반응 노트
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