Hydrochloric Acid → 5-(2-Acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoic acid

HRID 537063노트

반응식

HRID 537063 반응식
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:11]2[O:15][C:14]([Br:16])=[C:13]([C:17]([O:19]CC)=[O:18])[CH:12]=2)[C:8]([CH3:22])=[CH:7][N:6]=1)(=[O:3])[CH3:2].Cl>CCO.[OH-].[Na+]>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:11]2[O:15][C:14]([Br:16])=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=2)[C:8]([CH3:22])=[CH:7][N:6]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 66748591Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate

생성물 1

HCID 667484985-(2-Acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoic acid수율 54%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate (20 g, 54.6 mmol) in EtOH (240 mL) and 1M NaOH (80 mL) was allowed to stir at rt for 2 h. The reaction mixture was acidified with concentrated HCl to pH=3-4 and then filtered. The resulting solid was washed with water and dried to give 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoic acid (10.0 g, 43%).

후처리

  1. filtrationfiltered
  2. washThe resulting solid was washed with water
  3. customdried

출처 및 근거

ORD 기록
ord-befcb54a76a34e86a686e4b31fffdf6e
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859768B2

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