4-Chlorobenzonitrile → 4-Chlorobenzenehydroxamic acid

HRID 538553

반응식

HRID 538553 반응식
Cl[C:2]1[CH:9]=[CH:8][C:5]([C:6]#N)=[CH:4][CH:3]=1.[ClH:10].[NH2:11][OH:12].[OH-:13].[Na+]>CCO>[Cl:10][C:2]1[CH:9]=[CH:8][C:5]([C:6]([NH:11][OH:12])=[O:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 121634-ChlorobenzonitrileHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 5871784-Chlorobenzenehydroxamic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4-chlorobenzonitrile (10.0 g, 73.0 mmol) in EtOH (250 mL) was added hydroxylamine hydrochloride (5.03 g, 73.0 mmol) and NaOH (2.90 g, 73.0 mmol). The resulting reaction mixture was refluxed for 15 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuo and used as such for the next step (crude yield 12.0 g, 66%).

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas refluxed for 15 h
  3. customAfter the completion of the reaction (TLC monitoring)
  4. concentrationthe mixture was concentrated
  5. additionadded EtOH
  6. filtrationfiltered
  7. customThe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-cf0717949109400cad0d352f03afe04d
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865736B2

연결된 노트

불러오는 중…