Sodium Hydroxide → N'-Hydroxy-2H-1,3-Benzodioxole-5-Carboximidamide
반응식
O1[C:5]2[CH:6]=[CH:7][C:8]([C:10]#[N:11])=[CH:9][C:4]=2[O:3][CH2:2]1.Cl.[NH2:13][OH:14].[OH-:15].[Na+]>CCO>[OH:14][NH:13][C:10]([C:8]1[CH:7]=[CH:6][C:5]2[O:15][CH2:2][O:3][C:4]=2[CH:9]=1)=[NH:11]참가 물질
5
실험 절차
To a solution of Benzo[1,3]dioxole-5-carbonitrile (5.0 g, 33.9 mmol) in EtOH (100 mL) was added hydroxylamine hydrochloride (4.68 g, 67.90 mmol) and NaOH (2.71 g, 67.9 mmol). The resulting reaction mixture was refluxed for 12 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated under reduced pressure and used as such for the next step (crude yield 4.8 g, 78.68%).
후처리
- customThe resulting reaction mixture
- temperaturewas refluxed for 12 h
- customAfter the completion of the reaction (TLC monitoring)
- concentrationthe mixture was concentrated
- additionadded EtOH
- filtrationfiltered
- customThe filtrate was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ed4964eb1abe4136a714c129c4b0a833
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08865736B2
반응 노트
불러오는 중…