Hydrochloric Acid → 2-Aminophenol hydrochloride

HRID 538964

반응식

HRID 538964 반응식
[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])N.NC1C=CC=CC=1O.[ClH:18]>S(C1C=CC(C)=CC=1)([O-])(=O)=O.CO>[ClH:18].[NH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 58012-AminophenolHCID 19890176HCID 19890176, 화합물2회

생성물 1

HCID 58002-Aminophenol hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 85570p-Toluenesulfonate용매2회

실험 절차

In the present invention, the starting material 2-hydrazinylphenol may be in tosylate form. The 2-hydrazinylphenol in tosylate form can be prepared by a process comprising the steps of: (a) dissolving 2-aminophenol in methanol and adding hydrochloride gas thereto to obtain 2-aminophenol hydrochloride (HCl); (b) dissolving the 2-aminophenol hydrochloride in ethanol and adding isopentyl nitrite thereto to make a nitramide intermediate; and (c) adding the intermediate to an ethanol solution containing para-toluenesulfonic acid (PTSA or TsOH) and tin chloride (SnCl2), thereby obtaining 2-hydrazinylphenol tosylate.

출처 및 근거

ORD 기록
ord-ee621668dccd43c4895e91a335bdd852
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865934B2

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