Hydrochloric Acid → [(2,3-Difluorobenzoyl)amino]acetic acid

HRID 539589

반응식

HRID 539589 반응식
[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([O:10]C)=[O:9])=[O:5].[OH-].[Li+].Cl>CO.O>[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59816250Methyl [(2,3-difluorobenzoyl)amino]acetate

생성물 1

HCID 59816243[(2,3-Difluorobenzoyl)amino]acetic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

To a solution of methyl [(2,3-difluorobenzoyl)amino]acetate (0.250 g, 1.1 mmol) in methanol (7 mL) were added lithium hydroxide (0.053 g, 2.2 mmol) and water (3 mL). The reaction mixture was allowed to stir overnight. The mixture was diluted with water (20 mL) and acidified with 1N HCl (5 mL). The product was partitioned into DCM/methanol (4:1). The organic layer was dried over sodium sulfate and the solvent removed to give [(2,3-difluorobenzoyl)amino]acetic acid which was used in the next step without purification.

후처리

  1. customThe product was partitioned into DCM/methanol (4:1)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent removed

출처 및 근거

ORD 기록
ord-e403af05ceef40f88786cc3ccb137b08
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871745B2

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