Hydrochloric Acid → 2-Tert-butoxycarbonylamino-3-(2-hydroxy-4-methoxy-phenyl)propanoic acid

HRID 540413노트

반응식

HRID 540413 반응식
[OH-].[Na+].[C:3]([O:7][C:8]([NH:10][CH:11]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=1[OH:25])[C:12]([O:14]C)=[O:13])=[O:9])([CH3:6])([CH3:5])[CH3:4].Cl>O1CCCC1>[C:3]([O:7][C:8]([NH:10][CH:11]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=1[OH:25])[C:12]([OH:14])=[O:13])=[O:9])([CH3:5])([CH3:6])[CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 397418Methyl 2-tert-butoxycarbonylamino-3-(2-hydroxy-4-methoxyphenyl)-propanoate

생성물 1

HCID 669881482-Tert-butoxycarbonylamino-3-(2-hydroxy-4-methoxy-phenyl)propanoic acid수율 101.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5 ml of a 1N aqueous solution of sodium hydroxide are added to a solution of 850 mg (2.6 mmol) of methyl 2-tert-butoxycarbonylamino-3-(2-hydroxy-4-methoxyphenyl)-propanoate in 10 ml of tetrahydrofuran. The reaction medium is stirred for 4 hours at ambient temperature and then a 1N aqueous solution of hydrochloric acid is added until the pH is 1, and the medium is extracted with dichloromethane. The organic phase is dried over magnesium sulphate, filtered and evaporated. 820 mg of 2-tert-butoxycarbonylamino-3-(2-hydroxy-4-methoxy-phenyl)propanoic acid are obtained in the form of a beige powder with a quantitative yield.

후처리

  1. extractionthe medium is extracted with dichloromethane
  2. dry with materialThe organic phase is dried over magnesium sulphate
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-807e9f4bda234db3b1d8b8f9f36c4a67
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871187B2

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