Diethyl Oxalate → Ethyl 2-hydrazinyl-2-oxoacetate

HRID 541252

반응식

HRID 541252 반응식
[C:1]([O:8]CC)(=O)[C:2]([O:4][CH2:5][CH3:6])=[O:3].O.[NH2:12][NH2:13]>C(O)C>[NH:12]([C:1](=[O:8])[C:2]([O:4][CH2:5][CH3:6])=[O:3])[NH2:13]

참가 물질

4

반응물 2

HCID 7268Diethyl OxalateHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 2786935Ethyl 2-hydrazinyl-2-oxoacetate수율 88.5%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a round-bottom flask was added a solution of diethyl oxalate (10.0 g, 68.4 mmol, 1.00 equiv) in ethanol (100 mL). Hydrazine hydrate (2.75 g, 85.8 mmol, 1.00 equiv) was added and the resulting mixture was stirred for 3 h at 80° C. After cooling to ambient temperature, the solids were removed via filtration and the filtrate was concentrated in vacuo to yield 8.00 g (80%) of the title compound as a colorless oil.

후처리

  1. temperatureAfter cooling to ambient temperature
  2. customthe solids were removed via filtration
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-9d12edd2be484311be42d75512ec3b4e
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

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