Hydrazine hydrate (1:1) → (2R)-oxolane-2-carbohydrazide
반응식
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([OH:8])=O.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)[N:28]=[N:27]C=2C=1.O.NN>ClCCl>[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([NH:27][NH2:28])=[O:8]참가 물질
6
반응 조건
- 온도
- 25 °C
실험 절차
To a round-bottom flask was added a solution of (R)-tetrahydrofuran-2-carboxylic acid (3.00 g, 25.8 mmol, 1.00 equiv) in dichloromethane (60 mL). EDC.HCl (7.37 g, 38.5 mmol, 1.50 equiv), HOBt (5.24 g, 38.8 mmol, 1.50 equiv), and hydrazine hydrate (2.60 g, 51.9 mmol, 2.00 equiv) were added to the reaction. The resulting solution was stirred overnight at 25° C. The solids were removed with filtration. The filtrate was concentrated in vacuo to yield 2.00 g (59%) of (R)-tetrahydrofuran-2-carbohydrazide as a yellow oil.
후처리
- customThe solids were removed with filtration
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-3bff4fe272fe451c990ef9e6a97ec23a
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08871790B2
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