1,3-Dinitrobenzene → 1-Bromo-3,5-dinitrobenzene
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)([O-:3])=[O:2].[Br:13]N1C(=O)CCC1=O>S(=O)(=O)(O)O>[N+:1]([C:4]1[CH:9]=[C:8]([Br:13])[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)([O-:3])=[O:2]참가 물질
4
반응 조건
- 온도
- 85 °C
실험 절차
m-Dinitrobenzene (5.0 g, 0.030 mol) was stirred in sulfuric acid (50 mL) and heated to 85° C. N-Bromosuccinimide (5.0 g, 0.030 mol) was added in portions over 1.5 hours while maintaining a temperature of 85° C. The cooled mixture was poured into ice water and the precipitate was collected, washed with water and recrystallized from methanol to give the desired compound (5.9 g, 80%). LCMS for C6H4BrN2O4 (M+H)+: m/z=248.1.
후처리
- temperaturewhile maintaining a temperature of 85° C
- customthe precipitate was collected
- washwashed with water
- customrecrystallized from methanol
출처 및 근거
- ORD 기록
- ord-849f0c1eecfe4953b903c2eca6b00d16
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08871753B2
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