1,3-Dinitrobenzene → 1-Bromo-3,5-dinitrobenzene

HRID 541579

반응식

HRID 541579 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)([O-:3])=[O:2].[Br:13]N1C(=O)CCC1=O>S(=O)(=O)(O)O>[N+:1]([C:4]1[CH:9]=[C:8]([Br:13])[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 74521,3-DinitrobenzeneHCID 67184N-bromobutanimide

생성물 1

HCID 445341-Bromo-3,5-dinitrobenzene수율 80%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
85 °C

실험 절차

m-Dinitrobenzene (5.0 g, 0.030 mol) was stirred in sulfuric acid (50 mL) and heated to 85° C. N-Bromosuccinimide (5.0 g, 0.030 mol) was added in portions over 1.5 hours while maintaining a temperature of 85° C. The cooled mixture was poured into ice water and the precipitate was collected, washed with water and recrystallized from methanol to give the desired compound (5.9 g, 80%). LCMS for C6H4BrN2O4 (M+H)+: m/z=248.1.

후처리

  1. temperaturewhile maintaining a temperature of 85° C
  2. customthe precipitate was collected
  3. washwashed with water
  4. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-849f0c1eecfe4953b903c2eca6b00d16
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871753B2

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