Chloroform → N,N-dibenzyl-1-(oxiran-2-yl)methanamine

HRID 542201

반응식

HRID 542201 반응식
Cl[CH2:2][CH:3]([OH:20])[CH2:4][N:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[Na+].C(Cl)(Cl)Cl>O>[CH2:6]([N:5]([CH2:4][CH:3]1[CH2:2][O:20]1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 135354791-Chloro-3-dibenzylamino-2-propanol

생성물 1

HCID 11276836N,N-dibenzyl-1-(oxiran-2-yl)methanamine수율 76%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

50.7 g (0.175 mol) of 1-chloro-3-dibenzylamino-2-propanol, 9.5 g (0.24 mol) of sodium hydroxide and 5 ml of water are stirred together for 1 hour at 95° C. After the addition of 50 ml of chloroform and 20 ml of water, the phases are separated and the organic phase is washed with 20 ml of water, dehydrated with sodium sulphate and concentrated by evaporation. Vacuum distillation of the yellow oil obtained yields 33.7 g (76%) of the oxirane as a colourless oil.

후처리

  1. customthe phases are separated
  2. washthe organic phase is washed with 20 ml of water
  3. concentrationconcentrated by evaporation
  4. distillationVacuum distillation of the yellow oil
  5. customobtained

출처 및 근거

ORD 기록
ord-d75c00d5d21d4a309628e8166038e4f5
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04656180

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