Dimethyl Sulfate → 1-Bromo-3-methoxy-5-methylbenzene
반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[OH-].[Na+].S(OC)(O[CH3:16])(=O)=O>O>[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH3:16])[CH:5]=[C:6]([CH3:8])[CH:7]=1참가 물질
5
실험 절차
A mixture of 5-bromo-3-hydroxytoluene (93 g, 0.5 m) and sodium hydroxide (21 g, 0.5 m) in water (200 ml) is stirred at 10°, treated with dimethyl sulfate (63 g, 0.5 m) over 1 hour, refluxed for 2 hours and cooled. The mixture is diluted with water and extracted with ether. The ether extract is washed, dried with sodium sulfate and concentrated in vacuo to give 5-bromo-3-methoxytoluene.
후처리
- temperaturerefluxed for 2 hours
- temperaturecooled
- extractionextracted with ether
- extractionThe ether extract
- washis washed
- dry with materialdried with sodium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-463fc7d5baf7455d841575c1a42c4d3c
- 출처 데이터셋
- uspto-grants-1987_04
- 특허 번호
- US04659706
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