Chloroform → N,N-dibenzyl-1-(oxiran-2-yl)methanamine

HRID 542785

반응식

HRID 542785 반응식
Cl[CH2:2][CH:3]([OH:20])[CH2:4][N:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[Na+].C(Cl)(Cl)Cl>O>[CH2:6]([N:5]([CH2:4][CH:3]1[CH2:2][O:20]1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 135354791-Chloro-3-dibenzylamino-2-propanol

생성물 1

HCID 11276836N,N-dibenzyl-1-(oxiran-2-yl)methanamine수율 76%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

50.7 g (0.175 mol) of 1-chloro-3-dibenzylamino-2-propanol and 9.5 g (0.24 mol) of sodium hydroxide in 5 ml of water are stirred together for one hour at 95° c. After the addition of 50 ml of chloroform and 20 ml of water, the phases are separated and the organic phase is washed with 20 ml of water, dehydrated with sodium sulphate and concentrated by evaporation. Distillation of the resulting yellow oil under vacuum yields 33.7 g (76%) of the oxirane as a colourless oil.

후처리

  1. customthe phases are separated
  2. washthe organic phase is washed with 20 ml of water
  3. concentrationconcentrated by evaporation
  4. distillationDistillation of the resulting yellow oil under vacuum

출처 및 근거

ORD 기록
ord-77df8396dc084fb0a0092ea8b7aa3c41
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659721

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