Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid

HRID 543425

반응식

HRID 543425 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[I:13]Cl.O>C(O)(=O)C.II>[I:13][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[CH2:9][C:10]([OH:12])=[O:11]

참가 물질

6

반응물 3

HCID 962WaterHCID 15719(3-Methoxyphenyl)acetic acidHCID 24640Iodine chloride

생성물 1

HCID 8200712-(2-Iodo-5-methoxyphenyl)acetic acid수율 65%

시약·촉매·용매 2

HCID 807Iodine촉매HCID 176Acetic Acid용매

실험 절차

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

후처리

  1. customthe solid collected
  2. customIt was recrystallized from toluene

출처 및 근거

ORD 기록
ord-b4f7f8a97a8e42fb9576438e9b94f03a
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661635

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