Acetic Anhydride → n-[4-Chloro-3-(trifluoromethyl)phenyl]acetamide

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[C:5]([Cl:8])=[CH:6][CH:7]=1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:10])[F:11])[C:5]([Cl:8])=[CH:6][CH:7]=1)(=[O:15])[CH3:14]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 675744-Chloro-3-(trifluoromethyl)aniline

생성물 1

HCID 67676n-[4-Chloro-3-(trifluoromethyl)phenyl]acetamide수율 98.5%

실험 절차

A solution of 3-amino-6-chlorobenzotrifluoride (1.045 g, 5.34 mmol, Aldrich) in acetic anhydride (5 mL) was stirred at room temperature for 12 h to produce a white needle precipitate. It was filtered to give 1.250 g (98.5%) of 3-acetamido-6-chlorobenzotrifluoride. 1H NMR (CDCl3): δ2.193 (s, 3H); 7.420 (d, 1H, J=8.7 Hz); 7.726 (m, 2H), 7.804 (s, 1H).

후처리

customto produce a white needle precipitate
filtrationIt was filtered

출처 및 근거

ORD 기록: ord-1e1bfe82ffb14a0295567788d10cbeb5
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05622952

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