Hydrochloric Acid → 2-Ethoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid
반응식
[CH2:1]([O:3][N:4]=[C:5]([C:9]1[N:13]=[C:12]([NH:14]C=O)[S:11][N:10]=1)[C:6]([OH:8])=[O:7])[CH3:2].[OH-].[Na+].Cl>C(OCC)(=O)C>[CH2:1]([O:3][N:4]=[C:5]([C:9]1[N:13]=[C:12]([NH2:14])[S:11][N:10]=1)[C:6]([OH:8])=[O:7])[CH3:2]참가 물질
5
실험 절차
A mixture of 2-ethoxyimino-2-(5-formamido-1,2,4-thiadiazol-3-yl)acetic acid (syn isomer) (4.4 g) and 1 N aqueous solution of sodium hydroxide (54 ml) was stirred for 2 hours at 50° to 55° C. The mixture was cooled in an ice bath, acidified with hydrochloric acid (5.4 ml) and extracred with ethyl acetate. The extract was dried over magnesium sulfate and evaporated to dryness. The residue was triturated with diethyl ether to give 2-ethoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid (syn isomer) (2.92 g), mp. 168° to 170° C. (dec.).
후처리
- temperatureThe mixture was cooled in an ice bath
- dry with materialThe extract was dried over magnesium sulfate
- customevaporated to dryness
- customThe residue was triturated with diethyl ether
출처 및 근거
- ORD 기록
- ord-6b9a6bec9429434fb92086ca724621eb
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04447429
반응 노트
불러오는 중…