1-Acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene → 2-Nitro-3,5-bis(trifluoromethyl)aniline

HRID 54394

반응식

HRID 54394 반응식
C([NH:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]([F:18])([F:17])[F:16])[C:6]=1[N+:19]([O-:21])=[O:20])(=O)C>Cl.CCO>[N+:19]([C:6]1[C:7]([C:15]([F:16])([F:17])[F:18])=[CH:8][C:9]([C:11]([F:12])([F:13])[F:14])=[CH:10][C:5]=1[NH2:4])([O-:21])=[O:20]

참가 물질

4

반응물 1

HCID 199585741-Acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene

생성물 1

HCID 199585712-Nitro-3,5-bis(trifluoromethyl)aniline수율 71.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A mixture of 1-acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene (200 mg, 0.63 mmol) in concentrated HCl (3 mL) and EtOH (3 mL) was refluxed overnight, then it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 2-nitro-3,5-bis(trifluoromethyl)aniline 123 mg (71%). 1H NMR (DMSO-d6): δ6.392 (s, 2H), 7.131 (s, 1H), 7.375 (s, 1H).

후처리

  1. temperaturewas refluxed overnight
  2. extractionit was extracted by ethyl acetate (2×3 mL)
  3. dry with materialThe extract was dried over Mg2SO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-ce8d5eaebe7c42568d446175aca4b800
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622952

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