Phthalic Anhydride → 5-[2-[2-(Carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

HRID 5444

반응식

HRID 5444 반응식
[NH2:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1.[C:14]1(=[O:24])[O:19][C:17](=[O:18])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12>C(Cl)(Cl)Cl>[C:17]([C:16]1[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=1[C:14]([NH:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1)=[O:24])([OH:19])=[O:18]

참가 물질

4

반응물 2

HCID 6811Phthalic AnhydrideHCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

생성물 1

HCID 233628395-[2-[2-(Carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine수율 84.8%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

후처리

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureThe reaction mixture was cooled
  4. customThe crystals precipitated
  5. filtrationwere filtered off
  6. washwashed with chloroform
  7. customdried

출처 및 근거

ORD 기록
ord-201221c47b48468e8dcff804deda74d1
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244908

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