Hydrochloric Acid → Ethanol DMPE

반응식

[Cl-].[Na+].[CH3:3][P:4]([CH2:6][CH2:7][P:8]([CH3:10])[CH3:9])[CH3:5].Cl.[CH2:12]([OH:14])[CH3:13]>>[CH2:12]([OH:14])[CH3:13].[CH3:3][P:4]([CH2:6][CH2:7][P:8]([CH3:10])[CH3:9])[CH3:5]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 702Ethanol2회

HCID 5234Sodium Chloride2회

HCID 1410591,2-Bis(dimethylphosphino)ethane

생성물 1

HCID 131713514Ethanol DMPE수율 80%

실험 절차

Prepare a saturated solution of sodium chloride in ethanol by dissolving 117 mg of sodium chloride in 20 ml of degassed ethanol. Add 11.1 μl of liquid DMPE to this solution and adjust its pH to approximately 2.25 by adding concentrated hydrochloric acid. Dispense 5 ml into a 10 cc vial and crimp seal it using a teflon-coated stopper. Inject approximately 5 mCi of 99mTc-pertechnetate eluate into the vial and place it in a boiling water bath for 1 hour. HPLC analysis shows a yield of greater than 80% of the [99mTcCl2 (DMPE)2 ]+ complex.