Hydrogen Bromide → 5,6-Dihydro-4H-pyrrolo[3,4-d]thiazole Hydrobromide

HRID 546433노트

반응식

HRID 546433 반응식
C1(S([N:10]2[CH2:17][C:16]3[S:15][CH:14]=[N:13][C:12]=3[CH2:11]2)(=O)=O)C=CC=CC=1.C1(O)C=CC=CC=1.[BrH:25].C(OCC)(=O)C>O>[BrH:25].[S:15]1[C:16]2[CH2:17][NH:10][CH2:11][C:12]=2[N:13]=[CH:14]1

참가 물질

6

반응물 4

HCID 260Hydrogen BromideHCID 996PhenolHCID 8857Ethyl AcetateHCID 184428065-(benzenesulfonyl)-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole

생성물 1

HCID 184427795,6-Dihydro-4H-pyrrolo[3,4-d]thiazole Hydrobromide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5-(benzenesulfonyl)-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole (800 mg), phenol (800 μl) and 47% hydrobromic acid (5.00 ml) was heated under reflux for 2 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and water were added to conduct liquid separation. The resultant water layer was concentrated under reduced pressure. Ethyl acetate was added to the residue, colorless powder deposited was collected by filtration to obtain the title compound (521 mg).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customliquid separation
  4. concentrationThe resultant water layer was concentrated under reduced pressure
  5. additionEthyl acetate was added to the residue, colorless powder
  6. filtrationdeposited was collected by filtration

출처 및 근거

ORD 기록
ord-9d2b7fda0ab04235b69314818d1d2e51
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935824B2

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