2-Bromo-1-(4-hydroxyphenyl)ethanone → 4'-Hydroxyacetophenone

HRID 54695

반응식

HRID 54695 반응식
NC1N(CCN2CCOCC2)C2C=CC=CC=2N=1.[OH:19][C:20]1[CH:29]=[CH:28][C:23]([C:24](=[O:27])[CH2:25]Br)=[CH:22][CH:21]=1>C(Cl)(Cl)Cl.C(OCC)(=O)C>[OH:19][C:20]1[CH:29]=[CH:28][C:23]([C:24](=[O:27])[CH3:25])=[CH:22][CH:21]=1

참가 물질

5

반응물 2

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanoneHCID 5680111-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole

생성물 1

HCID 74694'-Hydroxyacetophenone

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 2-amino-1-(2-morpholinoethyl) benzimidazole (10 mmol, 2.46 g) and 4-hydroxyphenacyl bromide (10 mmol, 2.15 g) (obtained by bromination of para-hydroxyacetophenone with cupric bromide in a mixture of chloroform and ethyl acetate) is heated at reflux for 1 hour in 10 ml of dimethylformamide. After cooling, the mixture is poured into 50 ml of water and rendered alkaline with ammonium hydroxide. The resulting oil is removed and treated with water. The crystallised residue is filtered, dried, and recrystallised from ethanol.

출처 및 근거

ORD 기록
ord-256fd092d78a4b3982d8846e0ae85ff0
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623073

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