Hydrochloric Acid → HCID 22478250, 화합물

HRID 547176

반응식

HRID 547176 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:15])=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([F:24])[CH:18]=1.Cl>CC(O)C.CC(C)=O>[ClH:1].[Cl:15][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:21][C:20]3[CH:22]=[CH:23][C:17]([Cl:16])=[CH:18][C:19]=3[F:24])=[N:3][CH:4]=[N:5]2)=[CH:10][C:9]=1[N+:12]([O-:14])=[O:13]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 938984-Chloro-2-fluoroanilineHCID 104904554,7-Dichloro-6-nitroquinazoline

생성물 1

HCID 22478250HCID 22478250, 화합물수율 90%

시약·촉매·용매 2

HCID 180Acetone용매HCID 3776Isopropanol용매

실험 절차

A mixture of 4,7-dichloro-6-nitroquinazoline (24.4 g, 0.1 mol), 4-chloro-2-fluoroaniline and ethereal hydrogen chloride (100 ml of a 1M solution) in 2-propanol (600 ml) was heated at reflux for 1.5 hours. The mixture was allowed to cool and diluted with acetone. The solid product was collected by filtration, washed with acetone and dried to give 7-chloro-4-(4-chloro-2-fluoroanilino)-6nitroquinazoline hydrochloride (35.0 g, 90%) as a yellow powder.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 hours
  3. temperatureto cool
  4. filtrationThe solid product was collected by filtration
  5. washwashed with acetone
  6. customdried

출처 및 근거

ORD 기록
ord-9b64e283a6044048b2a081954f550360
출처 데이터셋
uspto-grants-2011_05
특허 번호
USRE042353E1

연결된 노트

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