Hydrochloric Acid → 2-methyl-2,3-dihydro-1H-indene-2-carboxylic acid
반응식
[CH3:1][C:2]1([C:11]([O:13]C)=[O:12])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.O.[OH-].[Li+].Cl>O1CCCC1.O.CO>[CH3:1][C:2]1([C:11]([OH:13])=[O:12])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1참가 물질
5
실험 절차
To a tetrahydrofuran/H2O/methanol (4 mL/1 mL/1 mL) solution of the methyl 2-methyl-2,3-dihydro-1H-indene-2-carboxylate (1.80 g, 9.46 mmol) was added lithium hydroxide monohydrate (1.19 g, 28.39 mmol). The reaction mixture stirred at ambient temperature for 4 hours and then the mixture was acidified to pH 3 using 1N HCl. The organics were extracted twice with 25 mL diethyl ether, the combined organics were washed with brine and then dried (Na2SO4), filtered and concentrated to as 2-Methyl-2,3-dihydro-1H-indene-2-carboxylic acid a white solid.
후처리
- extractionThe organics were extracted twice with 25 mL diethyl ether
- washthe combined organics were washed with brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated to as 2-Methyl-2,3-dihydro-1H-indene-2-carboxylic acid a white solid
출처 및 근거
- ORD 기록
- ord-72939a34af194ea6bd9e8ebb24592bb4
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07939528B2
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