Doxorubicin Hydrochloride → Doxorubicin
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C(C=C(C#N)C([O-])=O)CCC.[CH3:12][C@@H:13]1[O:18][C@@H:17]([O:19][C@@H:20]2[C:25]3=[C:26]([OH:43])[C:27]4[C:39](=[O:40])[C:38]5[C:33](=[CH:34][CH:35]=[CH:36][C:37]=5[O:41][CH3:42])[C:31](=[O:32])[C:28]=4[C:29]([OH:30])=[C:24]3[CH2:23][C@@:22]([OH:48])([C:44]([CH2:46][OH:47])=[O:45])[CH2:21]2)[CH2:16][C@H:15]([NH2:49])[C@@H:14]1[OH:50].Cl>Cl.O>[CH3:12][C@@H:13]1[O:18][C@@H:17]([O:19][C@@H:20]2[C:25]3=[C:26]([OH:43])[C:27]4[C:39](=[O:40])[C:38]5[C:33](=[CH:34][CH:35]=[CH:36][C:37]=5[O:41][CH3:42])[C:31](=[O:32])[C:28]=4[C:29]([OH:30])=[C:24]3[CH2:23][C@@:22]([OH:48])([C:44]([CH2:46][OH:47])=[O:45])[CH2:21]2)[CH2:16][C@H:15]([NH2:49])[C@@H:14]1[OH:50]참가 물질
5
실험 절차
100 μl of n-butylcyanoacrylate monomer was added to 1% dextran solution in 8 mL of 0.01 M HCl under constant stirring at 600 rpm. Doxorubicin hydrochloride powder 50 mg was dissolved in 2 mL of distilled water and after 40 minutes the solution was added to the reaction flask. After 4 hours the pH of the nanoparticle suspension was adjusted at 7 and filtered through 0.8 μm membrane filter (Nuclepore Track-Etch membrane, Whatman, USA). The doxorubicin-loaded nanoparticle suspension was kept in a refrigerator at 4° C.