Hydrochloric Acid → Lithium Chloride

HRID 55117노트

반응식

HRID 55117 반응식
C[O:2][C:3](=[O:19])[C@@H:4]1[CH2:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1.[Li+:20].[OH-].[ClH:22]>C1COCC1.O>[C:17]([C:14]1[CH:13]=[CH:12][C:11]([CH2:10][N:5]2[C:6](=[O:9])[CH2:7][CH2:8][C@H:4]2[C:3]([OH:19])=[O:2])=[CH:16][CH:15]=1)#[N:18].[Li+:20].[Cl-:22]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54410854N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester

생성물 2

HCID 433294Lithium ChlorideHCID 22872280N-(4-Cyanobenzyl)-L-pyroglutamic acid

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester (0.875 g, 0.0034 mol) was dissolved in THF:H2O (3:1) (12 mL) and treated with LiOH (0.294 g, 0.007 mol) with stirring at ambient temperature. After stirring for 3 h, the solution was neutralized with 1N HCl, and concentrated to dryness to give the title compound and 2.1 eq of LiCl which was used without further purification.

후처리

  1. stirringAfter stirring for 3 h
  2. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-f2485a4c07ac4dc0821a11680da6b71a
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624936

반응 노트

불러오는 중…