3-(Trifluoromethyl)phenol → 2-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

HRID 55121

반응식

HRID 55121 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].Cl[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH2:22][C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[N:16]=1>CN(C)C=O.[Cu]I>[S:25]1[CH:26]=[CH:27][C:23]([CH2:22][O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([O:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=3)[N:16]=2)=[CH:24]1

참가 물질

6

반응물 3

HCID 73763-(Trifluoromethyl)phenolHCID 24758Sodium hydrideHCID 199574132-Chloro-6-(3-thienylmethyloxy)pyridine

생성물 1

HCID 199574052-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 6228Dimethylformamide용매

실험 절차

To a solution containing meta-trifluoromethylphenol (3.62 g, 0.0045×5.0 mol), sodium hydride (0.89 g, (Ca.60% in mineral oil), 0.0045×5.0 mol) and CuI (0.42 g, 0.0045×0.5 mol) in dimethylformamide, 2-chloro-6-(3-thienylmethyloxy)pyridine (1.0 g, 0.0045 mol) was added and the resultant solution was refluxed for about 3 hours.

후처리

  1. additionwas added

출처 및 근거

ORD 기록
ord-6b619584c6cc4a48a4c6205325942da5
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624942

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