Acetic Anhydride → HCID 67199459, 화합물

HRID 551668노트

반응식

HRID 551668 반응식
O[CH:2]([CH2:8][CH2:9][CH:10]=[CH2:11])[CH:3]([CH3:7])[C:4]([OH:6])=O.C([O-])(=O)C.[K+].C(OC(=O)C)(=O)C>C(OCC)(=O)C>[CH3:7][C@@:3]12[C:4](=[O:6])[CH2:11][C@@H:10]1[CH2:9][CH:8]=[CH:2]2

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 517044Potassium AcetateHCID 14924162HCID 14924162, 화합물

생성물 1

HCID 67199459HCID 67199459, 화합물수율 19.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixed solution of 3-hydroxy-2-methylhept-6-enoic acid (5.45 g, 34.5 mmol), potassium acetate (7.0 g, 71.3 mmol), and acetic anhydride (30 mL) was stirred at room temperature for 1.5 hours and then stirred for 3 hours under conditions of heating to reflux. The reaction solution was left overnight, then diluted with ethyl acetate, washed with water, saturated aqueous sodium bicarbonate, and saturated saline, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography to obtain the compound of interest as a pale yellow oil (810 mg).

후처리

  1. temperatureof heating to reflux
  2. waitThe reaction solution was left overnight
  3. washwashed with water, saturated aqueous sodium bicarbonate, and saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure
  6. customthe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-1b70956e1f8d4004a6c914cdc674b12a
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947738B2

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