Guanidine Hydrochloride → 4-(dimethoxymethyl)pyrimidin-2-amine

HRID 552113노트

반응식

HRID 552113 반응식
[CH3:1][O:2][CH:3]([O:7][CH3:8])N(C)C.[CH3:9][C:10]([CH:12](OC)OC)=O.[OH-].[Na+].Cl.[NH2:20][C:21]([NH2:23])=[NH:22]>O>[CH3:8][O:7][CH:3]([O:2][CH3:1])[C:12]1[CH:10]=[CH:9][N:22]=[C:21]([NH2:23])[N:20]=1

참가 물질

6

반응물 4

HCID 5742Guanidine HydrochlorideHCID 14798Sodium HydroxideHCID 78373Dimethylformamide dimethyl acetalHCID 80650Pyruvic aldehyde dimethyl acetal

생성물 1

HCID 49130324-(dimethoxymethyl)pyrimidin-2-amine수율 36.6%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 5.5 mL (41 mmol, 1.0 eq.) of dimethylformamide dimethyl acetal and 5.0 mL (41 mmol, 1.0 eq.) pyruvic aldehyde dimethyl acetal was heated at 100° C. for 16 h. Methanol was removed in vacuo to afford a brown oil. A solution of 1.8 g (45 mmol, 1.1 eq.) of sodium hydroxide in 5 mL of water was added to a solution of 4.3 g (45 mmol, 1.1 eq.) of guanidine HCl in 10 mL of water. The resulting solution was added to the above described oil. The resulting mixture was stirred at room temperature for 48 h. The mixture was filtered to provide 2.5 g (15 mmol, 36%) of 2-aminopyrimidine-4-carboxaldehyde dimethylacetal (I-8).

후처리

  1. customMethanol was removed in vacuo
  2. customto afford a brown oil
  3. additionThe resulting solution was added to the
  4. filtrationThe mixture was filtered

출처 및 근거

ORD 기록
ord-d31f6c9f1c634c039334b5fbae7ea635
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951803B2

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