1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline
반응식
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>C1COCC1.[Ni]>[N:9]1([CH2:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:16][CH:15]=2)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1참가 물질
5
실험 절차
To a solution of 0.22 g (1.0 mmol, 1.0 eq.) of 1-(4-nitrobenzyl)piperidine (I-27) in 20 mL of THF was added ˜30 mg of Raney Nickel. The reaction mixture was stirred under at room temperature under 1 atm. of hydrogen for 12 h. The reaction mixture was through Celite® and the solvent removed in vacuo to provide 4-(piperidin-1-ylmethyl)benzenamine (I-28).
후처리
- customthe solvent removed in vacuo
출처 및 근거
- ORD 기록
- ord-92dcc1ce91b347c7bc84e34fbff6c632
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07951803B2
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