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Hydrochloric Acid → (E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoic acid

HRID 553901
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인쇄 미리보기

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HRID 553901 반응식
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1)/[CH:8]=[C:9]1/[C:10](=[O:29])[N:11]2[C@@H:16]([CH2:17][CH2:18]/1)[CH2:15][CH2:14][CH2:13][C@H:12]2[C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1.Cl>CO>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1)/[CH:8]=[C:9]1/[C:10](=[O:29])[N:11]2[C@@H:16]([CH2:17][CH2:18]/1)[CH2:15][CH2:14][CH2:13][C@H:12]2[C:19]1[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24779885methyl (E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoate

생성물 1

HCID 24780024(E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoic acid수율 99.1%

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

A 2 N sodium hydroxide solution (1 mL) was added to a solution of methyl (E)-4-{(4S*,9aR*)-7-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-6-oxooctahydroquinolizin-4-yl}benzoate (80 mg) in methanol (2 mL), and the reaction solution was stirred at room temperature for 18 hours. 2 N hydrochloric acid (1 mL) was added to the reaction solution, and the solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent: chloroform:methanol=5:1) to obtain 77 mg of the title compound. The property values of the compound are as follows.

후처리

  1. concentrationthe solution was concentrated under reduced pressure
  2. customThe resulting residue was purified by silica gel column chromatography (elution solvent: chloroform:methanol=5:1)

출처 및 근거

ORD 기록
ord-f9b18b2bec9d46dea9135d61af476da3
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08048878B2

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