Hydrochloric Acid → HCID 67465156, 화합물

HRID 554007

반응식

HRID 554007 반응식
C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1.[CH2:16]([O:18][C:19]([CH:21]=[CH:22][CH:23]1[NH:28][CH:27]([C:29]2[CH:34]=[C:33]([F:35])[C:32]([F:36])=[C:31]([F:37])[CH:30]=2)[CH2:26][N:25]([C:38]([O:40][CH3:41])=[O:39])[CH2:24]1)=[O:20])[CH3:17].[CH:42]([CH2:44][C:45](O)=[O:46])=[CH2:43].Cl>C1COCC1.C(OCC)(=O)C.C(N(CC)CC)C>[C:45]([N:28]1[CH:27]([C:29]2[CH:34]=[C:33]([F:35])[C:32]([F:36])=[C:31]([F:37])[CH:30]=2)[CH2:26][N:25]([C:38]([O:40][CH3:41])=[O:39])[CH2:24][CH:23]1[CH:22]=[CH:21][C:19]([O:18][CH2:16][CH3:17])=[O:20])(=[O:46])[CH2:44][CH:42]=[CH2:43]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 327433-Butenoic acidHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 67464101Methyl 3-(2-ethoxycarbonylvinyl)-5-(3,4,5-trifluorophenyl)piperazine-1-carboxylate

생성물 1

HCID 67465156HCID 67465156, 화합물

시약·촉매·용매 3

HCID 8028Tetrahydrofuran용매HCID 8471Triethylamine용매HCID 8857Ethyl Acetate용매

실험 절차

BOPCl (557 mg) was added to a solution of methyl 3-(2-ethoxycarbonylvinyl)-5-(3,4,5-trifluorophenyl)piperazine-1-carboxylate (422 mg), triethylamine (0.61 mL), and vinylacetic acid (0.19 mL) in THF (15 mL), and the reaction solution was stirred at room temperature for 20 hours. 1 N aqueous hydrochloric acid and ethyl acetate were added to the reaction solution, and the organic layer was separated. The resulting organic layer was washed with saturated sodium bicarbonate water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 643 mg of an E/Z isomer mixture crude product of the title compound. The property value of the compound is as follows.

후처리

  1. customthe organic layer was separated
  2. washThe resulting organic layer was washed with saturated sodium bicarbonate water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f3b38afad25c4244a2db0e2f777f6d1c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048878B2

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