Benzenesulfonyl chloride → HCID 66924673, 화합물

HRID 554272노트

반응식

HRID 554272 반응식
[Cl:1][C:2]1[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH3:13])[NH:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[H-].[Na+].[C:21]1([S:27](Cl)(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[Cl:1][C:2]1[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH3:13])[N:5]([S:27]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)(=[O:29])=[O:28])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 3

HCID 7369Benzenesulfonyl chlorideHCID 24758Sodium hydrideHCID 12808304Ethyl 4-chloro-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate

생성물 1

HCID 66924673HCID 66924673, 화합물수율 78.3%

실험 절차

Using ethyl 4-chloro-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate (509 mg), sodium hydride (60% in oil, 139 mg) and benzenesulfonyl chloride (511 mg), a procedure as in Reference Example 4 was performed to give the title compound as a pale-yellow oil (yield 610 mg, 78%).

출처 및 근거

ORD 기록
ord-223106ebc3f347c3ada31b9e78263ce3
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048909B2

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