Sodium borohydride → methyl 3-({4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}sulfonyl)benzoate

HRID 554423

반응식

[CH:1]([C:3]1[CH:4]=[C:5]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:6]([S:8]([C:11]2[CH:12]=[C:13]([CH:18]=[CH:19][CH:20]=2)[C:14]([O:16][CH3:17])=[O:15])(=[O:10])=[O:9])[CH:7]=1)=O.CO.[CH3:29][NH2:30].[BH4-].[Na+]>>[CH3:29][NH:30][CH2:1][C:3]1[CH:4]=[C:5]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:6]([S:8]([C:11]2[CH:12]=[C:13]([CH:18]=[CH:19][CH:20]=2)[C:14]([O:16][CH3:17])=[O:15])(=[O:10])=[O:9])[CH:7]=1

참가 물질

반응물 3

HCID 4311764Sodium borohydride

HCID 57454252Monomethylamine methanol

HCID 86620754Methyl 3-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate

생성물 1

HCID 66924818methyl 3-({4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}sulfonyl)benzoate수율 49%

실험 절차

Using methyl 3-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate (1.32 g), 40% methylamine methanol solution (416 mg) and sodium borohydride (100 mg), a procedure as in Reference Example 145 was performed to give the title compound as a pale-yellow oil (yield 668 mg, 49%).

출처 및 근거

ORD 기록: ord-3a72096dbdbd4086af1d88cd25cb363e
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08048909B2

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