Hydrochloric Acid → (5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid

HRID 554609노트

반응식

HRID 554609 반응식
C[O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[CH2:21][N:22]([C:25]([CH:27]2[CH2:29][CH2:28]2)=[O:26])[CH2:23][CH3:24])[CH:10]=1.CO.[OH-].[Na+].Cl>C1COCC1>[CH:27]1([C:25]([N:22]([CH2:21][C:12]2[CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=[CH:16][C:11]=2[C:9]2[CH:10]=[C:5]([CH2:4][C:3]([OH:30])=[O:2])[CH:6]=[N:7][CH:8]=2)[CH2:23][CH3:24])=[O:26])[CH2:29][CH2:28]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 67212307HCID 67212307, 화합물

생성물 1

HCID 45138480(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester (0.069 g, 0.16 mmol) was dissolved in THF (1 mL) and MeOH (0.8 mL) and treated with 1N aqueous NaOH (0.5 mL). The reaction was stirred at room temperature for 1 hour. The mixture was neutralized with 1N aqueous HCl and extracted twice with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated to give Compound 8.

후처리

  1. extractionextracted twice with CH2Cl2
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0bbe70d1583b4319a8a51bc85945ffb3
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08049015B2

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